Bruce Banner’s marriage to Betty Ross was interrupted by a crazed, drunken, gun-wielding soon-to-be-father-in-law, Bruce’s nemesis and sometime-ally General “Thunderbolt” Ross. He shot the best man, Rick Jones, before Betty yelled him into submission. Her haircut was atrocious.

The marriage of the very first Superman (the Superman of Earth-2) to Lois was the most normal of all. At the time they got married he had forgotten he was Superman and she didn’t discover the truth untill well after they were hitched. Superman was amnesiac because the Wizard hit him with a magic spell. Lois discovered that Clark was invulernable and stuff far later and figured the whole thing out. By taking the super out of Superman, albeit temporarily but in all ways, the normality of the union was insured. Until the Anti-Monitory attacked twenty or thirty years later.

The wedding of the Vision and Scarlet Witch…. I can’t remember. According to Marvels, written by Kurt Busiek, there were protests by normal non-super humans outside the church. That’s more of a recap/flashback than a genuine story.

The wedding of Havok and Polaris was screwed up by Chuck Austen, but they probably would have gotten together earlier if not for Polaris getting possessed by Malice, Havok secretly moving to Australia along with the rest of the X-Men while the world thought them dead. I don’t want to get into it.

Spider-Man got married twice with no problems (one marriage was in the daily newspaper comic strip and the other was in the Marvel Universe comic book).

Animated Spider-Man ended up marrying a Hydro-clone of Mary Jane and the ceremony was interrupted by an army of Mega-Goblin robots.

The second Green Goblin got married without problems.

I’m trying to think of more examples but I am blanking. Quicksilver’s marriage to Crystal was not notable. Good for them!

I’ve found a handful of villains with estranged, deceased or ex-spouses in their backgrounds, two ex-villains who reformed and married heroes (one only in flashback), several second-generation villains where you figure the previous one probably got married… during the 30 years he wasn’t being used as a villain! Only three villainous couples: the Joker and Harley Quinn, the Top and Golden Glider, and Punch and Jewelee. Of those, only Punch and Jewelee are married, and it’s not clear whether that was before or after they became villains. One villain (Blacksmith) who was introduced as another villain’s (Goldface) ex-wife.

I don’t know how it is in Marvel, but in the DCU, it looks like villains don’t get married until long after they retire.